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A molecular view of kinetochore assembly and function
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
The four causes: the functional architecture of centromeres and kinetochores
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
[HTML][HTML] Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics
A Campbell, S Fishel, N Bowman, S Duffy… - Reproductive …, 2013 - Elsevier
This study determined whether morphokinetic variables between aneuploid and euploid
embryos differ as a potential aid to select euploid embryos for transfer. Following …
embryos differ as a potential aid to select euploid embryos for transfer. Following …
Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome
In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …
Insights from biochemical reconstitution into the architecture of human kinetochores
Chromosomes are carriers of genetic material and their accurate transfer from a mother cell
to its two daughters during cell division is of paramount importance for life. Kinetochores are …
to its two daughters during cell division is of paramount importance for life. Kinetochores are …
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …
The composition, functions, and regulation of the budding yeast kinetochore
S Biggins - Genetics, 2013 - academic.oup.com
The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …
Higher-order protein assembly controls kinetochore formation
GB Sissoko, EV Tarasovetc, O Marescal… - Nature cell …, 2024 - nature.com
To faithfully segregate chromosomes during vertebrate mitosis, kinetochore–microtubule
interactions must be restricted to a single site on each chromosome. Prior work on pair-wise …
interactions must be restricted to a single site on each chromosome. Prior work on pair-wise …
Structure of the MIND complex defines a regulatory focus for yeast kinetochore assembly
YN Dimitrova, S Jenni, R Valverde, Y Khin… - Cell, 2016 - cell.com
Kinetochores connect centromeric nucleosomes with mitotic-spindle microtubules through
conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric …
conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric …
[HTML][HTML] Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization
Faithful chromosome segregation is mandatory for cell and organismal viability.
Kinetochores, large protein assemblies embedded in centromeric chromatin, establish a …
Kinetochores, large protein assemblies embedded in centromeric chromatin, establish a …