Modern tools for rapid diagnostics of antimicrobial resistance

A Vasala, VP Hytönen, OH Laitinen - Frontiers in cellular and infection …, 2020 - frontiersin.org
Fast, robust, and affordable antimicrobial susceptibility testing (AST) is required, as roughly
50% of antibiotic treatments are started with wrong antibiotics and without a proper …

Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Innovative and rapid antimicrobial susceptibility testing systems

A van Belkum, CAD Burnham, JWA Rossen… - Nature Reviews …, 2020 - nature.com
Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid
detection and quantification of resistance, combined with antimicrobial stewardship, are key …

Strategies to minimize antibiotic resistance

CR Lee, IH Cho, BC Jeong, SH Lee - International journal of …, 2013 - mdpi.com
Antibiotic resistance can be reduced by using antibiotics prudently based on guidelines of
antimicrobial stewardship programs (ASPs) and various data such as pharmacokinetic (PK) …

Developmental roadmap for antimicrobial susceptibility testing systems

A van Belkum, TT Bachmann, G Lüdke… - Nature Reviews …, 2019 - nature.com
Antimicrobial susceptibility testing (AST) technologies help to accelerate the initiation of
targeted antimicrobial therapy for patients with infections and could potentially extend the …

Antimicrobial susceptibility testing: currently used methods and devices and the near future in clinical practice

M Benkova, O Soukup, J Marek - Journal of applied …, 2020 - academic.oup.com
Rapid identification of pathogen and its resistance to antimicrobial drugs, and subsequent
appropriate antimicrobial treatment are essential for correct patient outcomes. Conventional …

Advances and challenges in biosensor-based diagnosis of infectious diseases

MLY Sin, KE Mach, PK Wong… - Expert review of molecular …, 2014 - Taylor & Francis
Rapid diagnosis of infectious diseases and timely initiation of appropriate treatment are
critical determinants that promote optimal clinical outcomes and general public health …

Deep learning analysis of vibrational spectra of bacterial lysate for rapid antimicrobial susceptibility testing

WJ Thrift, S Ronaghi, M Samad, H Wei, DG Nguyen… - ACS …, 2020 - ACS Publications
Rapid antimicrobial susceptibility testing (AST) is an integral tool to mitigate the unnecessary
use of powerful and broad-spectrum antibiotics that leads to the proliferation of multi-drug …

The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility

VN Kos, M Déraspe, RE McLaughlin… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Many clinical isolates of Pseudomonas aeruginosa cause infections that are difficult to
eradicate due to their resistance to a wide variety of antibiotics. Key genetic determinants of …

A rapid antimicrobial susceptibility test based on single-cell morphological analysis

J Choi, J Yoo, M Lee, EG Kim, JS Lee, S Lee… - Science translational …, 2014 - science.org
A rapid antibiotic susceptibility test (AST) is desperately needed in clinical settings for fast
and appropriate antibiotic administration. Traditional ASTs, which rely on cell culture, are not …