Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by
the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of …

DNA vaccine strategies can differ greatly, with significant effects on the outcome of
immunization. In this article, we discuss plasmid design strategies and vaccine regimens …

Japanese encephalitis (JE), a mosquito-borne flaviviral infection, is the leading recognized
cause of childhood encephalitis in Asia. After, yellow fever (YF), JE is the second Flavivirus …

Previously, we demonstrated that an experimental smallpox DNA vaccine comprised of four
vaccinia virus genes (4pox) administered by gene gun elicited protective immunity in mice …

Fish nodaviruses (betanodaviruses) are small, non-enveloped icosahedral single-stranded
positive-sense RNA viruses that can cause viral encephalopathy and retinopathy (VER) in a …

Due to their widespread geographic distribution and frequent outbreaks, mosquito-borne
flaviviruses, such as DENV (DENV), Zika virus (ZIKV), Japanese encephalitis virus (JEV) …

In 1990 a new approach for vaccination was invented involving injection of plasmid DNA in
vivo, which elicits an immune response to the encoded protein. DNA vaccination can …

Background: Japanese encephalitis (JE) is a significant cause of human morbidity and
mortality throughout Asia. Vaccines for JE have been available for many years and their use …

We analyzed four DNA vaccines based on DENV-2 NS1: pcENS1, encoding the C-terminal
from E protein plus the NS1 region; pcENS1ANC, similar to pcENS1 plus the N-terminal …

Dengue is one of the most important arboviral diseases in humans, and although efforts over
the last decades have dealt with the development of a vaccine, this vaccine is not available …