Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that
somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) …

Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in
recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and …

The development of human-induced pluripotent stem cells (hiPSCs) has made possible
patient-specific modeling across the spectrum of human disease. Here, we discuss recent …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their
differentiation into neural lineages is a revolutionary experimental system for studying …

Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex
human tissues that recapitulate features of architecture, composition and function of in vivo …

Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity
impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) …

Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls
for disease-modeling studies. Here we apply precision health to create a high-quality …

The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased
worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research …

Genetic and molecular mechanisms that play a causal role in mental illnesses are
challenging to elucidate, particularly as there is a lack of relevant in vitro and in vivo models …