The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ
autoimmune disease and inflammation. This indicates that in a normal immune system …

Background: Tumor associated macrophages (TAMs) have strong plasticity and if
reprogrammed, can clear tumor cells and regulate the adaptive immune system for cancer …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Regulatory T (Treg) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity. Conversely, Treg …

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of …