Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for
about 90% of cancer deaths. Although cancer survival rate has been significantly improved …

Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for treatment of
glioblastomas and in phase II for several other tumors. This drug is the first anti-angiogenic …

Le remodelage de la matrice extracellulaire indispensable à la cicatrisation des blessures,
l'embryogenèse, l'angiogenèse ou le cycle reproducteur féminin nécessite l'action des …

As cancer cells undergo metastasis—invasion and migration of a new tissue—they
penetrate and attach to the target tissue's basal matrix. This allows the cancer cell to pull …

Cell migration in three-dimensional (3-D) extracellular matrix (ECM) is not a uniform event
but rather comprises a modular spectrum of interdependent biophysical and biochemical …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Chemokines provide directional cues for leukocyte migration and activation that are
essential for normal leukocytic trafficking and for host responses during processes such as …

Primary brain tumors (gliomas) have the unusual ability to diffusely infiltrate the normal brain
thereby evading surgical treatment. Chlorotoxin is a scorpion toxin that specifically binds to …

Toward the goal of develo** an optical imaging contrast agent that will enable surgeons to
intraoperatively distinguish cancer foci from adjacent normal tissue, we developed a …

Laminin-5 (Ln-5) is an extracellular matrix substrate for cell adhesion and migration, which is
found in many epithelial basement membranes. Mechanisms eliciting migration on Ln-5 …