An update on the human and animal enteric pathogen Clostridium perfringens

R Kiu, LJ Hall - Emerging microbes & infections, 2018 - Taylor & Francis
Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of> 20
virulent toxins, has been associated with intestinal diseases in both animals and humans …

Pathogenicity and virulence of Clostridium perfringens

I Mehdizadeh Gohari, M A. Navarro, J Li, A Shrestha… - Virulence, 2021 - Taylor & Francis
Clostridium perfringens is an extremely versatile pathogen of humans and livestock, causing
wound infections like gas gangrene (clostridial myonecrosis), enteritis/enterocolitis …

Towards an Understanding of the Role of Clostridium Perfringens Toxins in Human and Animal Disease

FA Uzal, JC Freedman, A Shrestha, JR Theoret… - Future …, 2014 - Taylor & Francis
Clostridium perfringens uses its arsenal of> 16 toxins to cause histotoxic and intestinal
infections in humans and animals. It has been unclear why this bacterium produces so many …

Role of pore-forming toxins in bacterial infectious diseases

FCO Los, TM Randis, RV Aroian… - … and Molecular Biology …, 2013 - Am Soc Microbiol
Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins

MA Navarro, BA McClane, FA Uzal - Toxins, 2018 - mdpi.com
Clostridium perfringens uses its large arsenal of protein toxins to produce histotoxic,
neurologic and intestinal infections in humans and animals. The major toxins involved in …

Toxin plasmids of Clostridium perfringens

J Li, V Adams, TL Bannam, K Miyamoto… - Microbiology and …, 2013 - Am Soc Microbiol
In both humans and animals, Clostridium perfringens is an important cause of histotoxic
infections and diseases originating in the intestines, such as enteritis and enterotoxemia …

Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens

AL Keyburn, SA Sheedy, ME Ford… - Infection and …, 2006 - Am Soc Microbiol
The Clostridium perfringens alpha-toxin has previously been implicated as the major
virulence factor in necrotic enteritis in chickens, although definitive proof has not been …

[HTML][HTML] Clostridium perfringens toxins involved in mammalian veterinary diseases

FA Uzal, JE Vidal, BA McClane… - The open toxinology …, 2010 - ncbi.nlm.nih.gov
Clostridium perfringens is a gram-positive anaerobic rod that is classified into 5 toxinotypes
(A, B, C, D, and E) according to the production of 4 major toxins, namely alpha (CPA), beta …

Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens

GSA Myers, DA Rasko, JK Cheung, J Ravel… - Genome …, 2006 - genome.cshlp.org
Clostridium perfringens is a Gram-positive, anaerobic spore-forming bacterium commonly
found in soil, sediments, and the human gastrointestinal tract. C. perfringens is responsible …

Clostridial toxins

MR Popoff, P Bouvet - Future microbiology, 2009 - Taylor & Francis
Clostridia produce the highest number of toxins of any type of bacteria and are involved in
severe diseases in humans and other animals. Most of the clostridial toxins are pore-forming …