Although many new anti-infectives have been discovered and developed solely using
phenotypic cellular screening and assay optimization, most researchers recognize that …

Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a
counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes …

Autophagy and the ubiquitin-proteasome system (UPS) are two major protein degradation
pathways implicated in the response to microbial infections in eukaryotes. In animals, the …

Naturally derived chemical compounds are the foundation of much of our pharmacopeia,
especially in antiproliferative and anti-infective drug classes. Here, we report that a naturally …

Introduction Leishmaniasis is a neglected tropical infectious disease. The available limited
therapeutic options for leishmaniasis are inadequate due to their poor pharmacokinetic …

The protozoan parasite Trichomonas vaginalis (Tv) causes trichomoniasis, the most
common non‐viral sexually transmitted infection in the world. Although Tv has been linked to …

The proteasome plays a vital role throughout the life cycle as Plasmodium parasites quickly
adapt to a new host and undergo a series of morphologic changes during asexual …

Tick-transmitted Babesia are a major global veterinary threat and an emerging risk to
humans. Unlike their Plasmodium relatives, these erythrocyte-infecting Apicomplexa have …

Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …

The microsporidia Nosema ceranae is an obligate intracellular parasite that causes honey
bee mortality and contributes to colony collapse. Fumagillin is presently the only …