The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Abstract Na+/Cl–-coupled biogenic amine transporters are the primary targets of therapeutic
and abused drugs, ranging from antidepressants to the psychostimulants cocaine and …

Abstract Antidepressants targeting Na+/Cl−-coupled neurotransmitter uptake define a key
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying …

The dopamine (DA) transporter (DAT) controls the spatial and temporal dynamics of DA
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …

The dopamine transporter has a crucial role in regulation of dopaminergic
neurotransmission by uptake of dopamine into neurons and contributes to the abuse …

The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT)
ensures the phasic nature of the DA signal, which underlies the ability of DA to encode …

Lasker's award-winning drug propofol is widely used in general anesthesia. The
recreational use of propofol is reported to produce a well-rested feeling and euphoric state; …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …