Duchenne muscular dystrophy is a severe, progressive, muscle-wasting disease that leads
to difficulties with movement and, eventually, to the need for assisted ventilation and …

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin gene
mutation. Conceptually, replacing the mutated gene with a normal one would cure the …

Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule
involved in a wide range of cellular and physiological processes. These enzymes comprise …

The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

Modified muscle use or injury can produce a stereotypic inflammatory response in which
neutrophils rapidly invade, followed by macrophages. This inflammatory response coincides …

In the past five years, skeletal muscle has emerged as a paradigm of “nitric oxide”(NO)
function and redox-related signaling in biology. All major nitric oxide synthase (NOS) …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Skeletal muscle continuously adapts to changes in its mechanical environment through
modifications in gene expression and protein stability that affect its physiological function …

Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

Nitric oxide (NO) is synthesised from l-arginine by the enzyme NO synthase (NOS). The
complex reaction involves the transfer of electrons from NADPH, via the flavins FAD and …