Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The
NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …

Curcumin is well known as a potent antioxidant and free radical scavenger and has great
potential for anti-aging applications. In this study, we investigate the molecular mechanism …

Abstract Impaired insulin/IGF-1 signaling (IIS) and caloric restriction (CR) prolong lifespan in
the nematode C. elegans. However, a cross comparison of these longevity pathways using a …

Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and
thermotolerance in the nematode C. elegans. Malate can be synthesized from fumarate by …

Aging is characterized by progressive loss of cellular function and integrity. It has been
thought to be driven by stochastic molecular damage. However, genetic and environmental …

Many lines of evidence point to links between sleep regulation and energy homeostasis, but
mechanisms underlying these connections are unknown. During Caenorhabditis elegans …