BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Abstract In 2010, Richard Heck, Ei‐ichi Negishi, and Akira Suzuki joined the prestigious
circle of Nobel Laureate chemists for their roles in discovering and develo** highly …

Natural products and their derivatives have historically been invaluable as a source of
therapeutic agents. However, in the past decade, research into natural products in the …

Although traditionally natural products have played an important role in drug discovery, in
the past few years most Big Pharma companies have either terminated or considerably …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

451 lenge, both for experiment and theory. A central question is what the right level of
description is when constructing quantitative models of large or even systemwide genetic …

Herein we present a review on methods for carbonyl reductions on large scale (≥ 100
mmol) applied to the synthesis of drug candidates in the pharmaceutical industry. We …