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The role of PD-1 in acute and chronic infection
PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
Intracellular pathogens: host immunity and microbial persistence strategies
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …
are ranked as the second leading cause of death worldwide by the World Health …
HIV‐associated chronic immune activation
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
Natural regulatory T cells in infectious disease
This review discusses the control exerted by natural CD4+ CD25+ regulatory T cells (natural
Treg cells) during infectious processes. Natural Treg cells may limit the magnitude of effector …
Treg cells) during infectious processes. Natural Treg cells may limit the magnitude of effector …
Extracellular ATP and adenosine: The Yin and Yang in immune responses?
Abstract Extracellular adenosine 5′-triphosphate (ATP) and adenosine molecules are
intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is …
intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is …
Regulatory T cells and infection: a dangerous necessity
Surviving a given infection requires the generation of a controlled immune response. Failure
to establish or restore homeostatic conditions during or following the onset of an infection …
to establish or restore homeostatic conditions during or following the onset of an infection …
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible
individuals. Both naturally occurring CD4+ CD25+ regulatory T cells and inducible …
individuals. Both naturally occurring CD4+ CD25+ regulatory T cells and inducible …
Regulatory T cells: friend or foe in immunity to infection?
Homeostasis in the immune system depends on a balance between the responses that
control infection and tumour growth and the reciprocal responses that prevent inflammation …
control infection and tumour growth and the reciprocal responses that prevent inflammation …
The development and function of regulatory T cells
CJ Workman, AL Szymczak-Workman… - Cellular and molecular …, 2009 - Springer
Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance.
There are two types of Tregs: natural Tregs, which develop in the thymus, and induced …
There are two types of Tregs: natural Tregs, which develop in the thymus, and induced …
IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage
A O'Garra, PL Vieira, P Vieira, AE Goldfeld - The Journal of clinical …, 2004 - jci.org
Effective immune responses against pathogens are sometimes accompanied by strong
inflammatory reactions. To minimize damage to self, the activation of the immune system …
inflammatory reactions. To minimize damage to self, the activation of the immune system …