[KNJIGA][B] An introduction to physical oncology: How mechanistic mathematical modeling can improve cancer therapy outcomes
Physical oncology has the potential to revolutionize cancer research and treatment. The
fundamental rationale behind this approach is that physical processes, such as transport …
fundamental rationale behind this approach is that physical processes, such as transport …
BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research
Reconstructing gene regulatory networks (GRNs) from gene expression data is a
challenging problem. Existing GRN reconstruction algorithms can be broadly divided into …
challenging problem. Existing GRN reconstruction algorithms can be broadly divided into …
Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case
Background Model based design plays a fundamental role in synthetic biology. Exploiting
modularity, ie using biological parts and interconnecting them to build new and more …
modularity, ie using biological parts and interconnecting them to build new and more …
Lower glycolysis carries a higher flux than any biochemically possible alternative
The universality of many pathways of core metabolism suggests a strong role for
evolutionary selection, but it remains unclear whether existing pathways have been selected …
evolutionary selection, but it remains unclear whether existing pathways have been selected …
Finding robust adaptation gene regulatory networks using multi-objective genetic algorithm
HP Ren, XN Huang, JX Hao - IEEE/ACM Transactions on …, 2015 - ieeexplore.ieee.org
Robust adaptation plays a key role in gene regulatory networks, and it is thought to be an
important attribute for the organic or cells to survive in fluctuating conditions. In this paper, a …
important attribute for the organic or cells to survive in fluctuating conditions. In this paper, a …
Signaling cascades transmit information downstream and upstream but unlikely simultaneously
Background Signal transduction is the process through which cells communicate with the
external environment, interpret stimuli and respond to them. This mechanism is controlled by …
external environment, interpret stimuli and respond to them. This mechanism is controlled by …
Robustness in spatially driven bistability in signaling systems
Biological systems are spatially organized. This microscopic heterogeneity has been shown
to produce emergent complex behaviors such as bistability. Even though the connection …
to produce emergent complex behaviors such as bistability. Even though the connection …
Quantitative lifecycle risk analysis of the development of a just-in-time transportation network system
JPT Mo, M Cook - Advanced Engineering Informatics, 2018 - Elsevier
The automotive manufacturing industry is under financial pressure due to massive cost
structure, relatively small scale operation and strong global competition. In order to improve …
structure, relatively small scale operation and strong global competition. In order to improve …
A Noise-Tolerating Gene Association Network Uncovering an Oncogenic Regulatory Motif in Lymphoma Transcriptomics
In cancer genomics research, gene expressions provide clues to gene regulations
implicating patients' risk of survival. Gene expressions, however, fluctuate due to noises …
implicating patients' risk of survival. Gene expressions, however, fluctuate due to noises …
Host-circuit interactions explain unexpected behavior of a gene circuit.
Mathematical models are powerful tools for the design of gene circuits in synthetic biology.
Models can predict circuit behavior and guide the selection of suitable circuit components …
Models can predict circuit behavior and guide the selection of suitable circuit components …