The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most
versatile family of membrane receptors, are also the most common target of therapeutic …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

The mechanisms underlying the progression of diabetes mellitus and heart failure are
closely intertwined, such that worsening of one condition is frequently accompanied by …

G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the
largest single family of integral membrane receptors. GPCRs transduce information provided …

Among membrane‐bound receptors, the G protein‐coupled receptors (GPCRs) are certainly
the most diverse. They have been very successful during evolution, being capable of …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …

Advances in structural biology have provided important mechanistic insights into signaling
by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …