Regulation of muscle potassium: exercise performance, fatigue and health implications

MI Lindinger, SP Cairns - European Journal of Applied Physiology, 2021 - Springer
This review integrates from the single muscle fibre to exercising human the current
understanding of the role of skeletal muscle for whole-body potassium (K+) regulation, and …

Exercise and fatigue: integrating the role of K+, Na+ and Cl in the regulation of sarcolemmal excitability of skeletal muscle

JM Renaud, N Ørtenblad, MJ McKenna… - European Journal of …, 2023 - Springer
Perturbations in K+ have long been considered a key factor in skeletal muscle fatigue.
However, the exercise-induced changes in K+ intra-to-extracellular gradient is by itself …

Utilizing physiological principles of motor unit recruitment to reduce fatigability of electrically-evoked contractions: a narrative review

TS Barss, EN Ainsley, FC Claveria-Gonzalez… - Archives of physical …, 2018 - Elsevier
Neuromuscular electrical stimulation (NMES) is used to produce contractions to restore
movement and reduce secondary complications for individuals experiencing motor …

The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle

X Wang, M Nawaz, C DuPont, JH Myers, SRA Burke… - Elife, 2022 - elifesciences.org
Excitation-contraction coupling (ECC) is the process by which electrical excitation of muscle
is converted into force generation. Depolarization of skeletal muscle resting potential …

Biochemical aspects and therapeutic mechanisms of cannabidiol in epilepsy

APA Boleti, BEF Frihling, PS e Silva… - Neuroscience & …, 2022 - Elsevier
Epilepsy is a chronic neurological disease characterized by recurrent epileptic seizures.
Studies have shown the complexity of epileptogenesis and ictogenesis, in which …

Muscle ionic shifts during exercise: implications for fatigue and exercise performance

M Hostrup, SP Cairns, J Bangsbo - Comprehensive Physiology, 2011 - Wiley Online Library
Exercise causes major shifts in multiple ions (eg, K+, Na+, H+, lactate–, Ca2+, and Cl–)
during muscle activity that contributes to development of muscle fatigue. Sarcolemmal …

Moderately elevated extracellular [K+] potentiates submaximal force and power in skeletal muscle via increased [Ca2+]i during contractions

KK Pedersen, AJ Cheng… - … of Physiology-Cell …, 2019 - journals.physiology.org
The extracellular K+ concentration ([K+] o) increases during physical exercise. We here
studied whether moderately elevated [K+] o may increase force and power output during …

Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro

K Overgaard, W Gittings, R Vandenboom - Pflügers Archiv-European …, 2022 - Springer
The influence of moderately elevated extracellular potassium concentration ([K+]) on muscle
force has marked similarities to that of posttetanic potentiation (PTP) in that twitch force may …

Longitudinal and transversal propagation of excitation along the tubular system of rat fast‐twitch muscle fibres studied by high speed confocal microscopy

JN Edwards, TR Cully, TR Shannon… - The Journal of …, 2012 - Wiley Online Library
Non‐technical summary Contraction of the vertebrate skeletal muscle is dependent on the
excitation of the highly specialized plasma membrane of individual muscle fibres. Most of the …

Prevalence and associated factors of postoperative suxamethonium-induced myalgia in surgical patients at Debre Tabor Comprehensive Specialized Hospital …

B Chekol, N Zurbachew, G Mekete, E Bayuh… - Scientific Reports, 2024 - nature.com
Suxamethonium is considered by many to be the best drug for providing ideal intubating
conditions, short surgical procedures, and rapid sequence induction. However, its …