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A general introduction to glucocorticoid biology
S Timmermans, J Souffriau, C Libert - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …
Therapeutic mechanisms of glucocorticoids
Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …
Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …
specific gene expression rhythms and how these depend on age and sex is not defined in …
Glucocorticoids—all-rounders tackling the versatile players of the immune system
C Strehl, L Ehlers, T Gaber, F Buttgereit - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …
More than suppression: glucocorticoid action on monocytes and macrophages
JM Ehrchen, J Roth, K Barczyk-Kahlert - Frontiers in immunology, 2019 - frontiersin.org
Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …
Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction
Enhanced susceptibility to inflammatory and autoimmune disease can be related to
impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid …
impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid …
[HTML][HTML] The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …
inflammatory effects, they have been amongst the most widely used and effective treatments …
The role of glucocorticoids in inflammatory diseases
For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable
treatment option for inflammatory diseases. However, their benefits do not come without a …
treatment option for inflammatory diseases. However, their benefits do not come without a …
Mechanisms involved in the side effects of glucocorticoids
H Schäcke, WD Döcke, K Asadullah - Pharmacology & therapeutics, 2002 - Elsevier
Glucocorticoids (GCs) represent the most important and frequently used class of anti-
inflammatory drugs. While the therapeutic effects of GCs have been known and used for …
inflammatory drugs. While the therapeutic effects of GCs have been known and used for …
How stress influences the immune response
DA Padgett, R Glaser - Trends in immunology, 2003 - cell.com
In response to a stressor, physiological changes are set into motion to help an individual
cope with the stressor. However, chronic activation of these stress responses, which include …
cope with the stressor. However, chronic activation of these stress responses, which include …