Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …

Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The
prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are …

Intensification of aquaculture practices resulted in increased ammonia production in the
culture systems. Lack of proper management of the culture system will result in elevated …

In mammals, the neuroendocrine system, which includes the communication between the
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …

A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …

Chronic stress can affect human health through a myriad of behavioral and biochemical
pathways. This review focuses on some key hormonal and metabolic pathways that appear …

Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …

Older people constitute an increasingly greater proportion of patients with advanced CKD,
including those patients undergoing maintenance dialysis treatment. Frailty is a biologic …