[HTML][HTML] Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens
Single-cell genomics enables dissection of tumor heterogeneity and molecular
underpinnings of drug response at an unprecedented resolution,,,,,,,,,–. However, broad …
underpinnings of drug response at an unprecedented resolution,,,,,,,,,–. However, broad …
The CD58–CD2 axis in cancer immune evasion
M Quastel, M Dustin - Nature Reviews Immunology, 2022 - nature.com
Journal Club Page 1 NATuRe RevIews | Immunology 0123456789();: So how are immune
cell populations affected in the involved nodes? Single cell profiling showed several changes …
cell populations affected in the involved nodes? Single cell profiling showed several changes …
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors
Chimeric antigen receptors (CARs) can redirect T cells to target abnormal cells, but their
activity is limited by a profound defect in antigen sensitivity, the source of which remains …
activity is limited by a profound defect in antigen sensitivity, the source of which remains …
Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia
D Leongamornlert, J Gutiérrez-Abril, SW Lee… - Blood …, 2023 - ashpublications.org
Genomic profiling during the diagnosis of B-cell precursor acute lymphoblastic leukemia
(BCP-ALL) in adults is used to guide disease classification, risk stratification, and treatment …
(BCP-ALL) in adults is used to guide disease classification, risk stratification, and treatment …
Proceedings from the Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA)
Mucosal melanoma remains a rare cancer with high mortality and a paucity of therapeutic
options. This is due in significant part to its low incidence leading to limited patient access to …
options. This is due in significant part to its low incidence leading to limited patient access to …
Co-stimulatorische CD2-gerichtete Immunliganden zur Verstärkung der ADCC-Aktivität therapeutischer Antikörper in der Lymphomtherapie
AM Albici - 2023 - macau.uni-kiel.de
Falle einer malignen Transformation als aberrant zu erkennen und zu eliminieren (Burnet,
1970). Die Funktionalität der Immunzellen ist für den korrekten Ablauf solcher Mechanismen …
1970). Die Funktionalität der Immunzellen ist für den korrekten Ablauf solcher Mechanismen …