Stretch-induced endogenous electric fields drive directed collective cell migration in vivo

F Ferreira, S Moreira, M Zhao, EH Barriga - Nature Materials, 2025 - nature.com
Directed collective cell migration is essential for morphogenesis, and chemical, electrical,
mechanical and topological features have been shown to guide cell migration in vitro. Here …

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

V Rayaprolu, HM Miettinen, WD Baker… - Journal of General …, 2024 - rupress.org
The voltage-sensing domain (VSD) is a four-helix modular protein domain that converts
electrical signals into conformational changes, leading to open pores and active enzymes. In …

Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes

A Ratanayotha, M Matsuda, Y Kimura… - Communications …, 2022 - nature.com
Voltage-sensing phosphatase (Vsp) is a unique membrane protein that translates
membrane electrical activities into the changes of phosphoinositide profiles. Vsp orthologs …

Insight into the function of voltage-sensing phosphatase in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni

A Ratanayotha, A Iida, J Nomura… - American Journal …, 2024 - journals.physiology.org
Nutrient absorption is essential for animal survival and development. Our previous study on
zebrafish reported that nutrient absorption in lysosome-rich enterocytes (LREs) is promoted …

Stretch-induced endogenous electric fields drive neural crest directed collective cell migration in vivo

F Ferreira, S Moreira, EH Barriga - bioRxiv, 2021 - biorxiv.org
Directed collective cell migration (dCCM) is essential for morphogenesis,. Cell clusters
migrate in inherently complex in vivo environments composed of chemical, electrical …

What voltage-sensing phosphatases can reveal about the mechanisms of ion channel regulation by phosphoinositides

Y Okamura, D Yoshioka - Biochemical Society Transactions, 2023 - portlandpress.com
Many membrane proteins including ion channels and ion transporters are regulated by
membrane phospholipids such as phosphoinositides in cell membranes and organelles …

S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing

V Rayaprolu, HM Miettinen, W Baker, VC Young… - bioRxiv, 2023 - biorxiv.org
The voltage sensing domain (VSD) is a four-helix modular protein domain that converts
electrical signals into conformational changes, leading to open pores and active enzymes. In …

Genome-wide survey of tyrosine phosphatases in thirty mammalian genomes

T Bhattacharyya, R Sowdhamini - Cellular Signalling, 2021 - Elsevier
The age of genomics has given us a wealth of information and the tools to study whole
genomes. This, in turn, has facilitated genome-wide studies among organisms that were …