Obesity-related heart failure with a preserved ejection fraction (HFpEF) is an important
phenotype prevalent in the community, especially in people with metabolic disorders (eg …

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular
morbidity and mortality. Capillary rarefaction may be both one of the causes as well as a …

A major complication of hypertension is microvascular damage and capillary rarefaction is a
known complication of hypertensive end-organ damage which confers a higher risk of …

This study examined in vivo (1) skeletal muscle oxygenation and microvascular function, at
rest and during handgrip exercise, and (2) their association with macrovascular function and …

Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the
surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted …

Skin microcirculation has been proposed as a model of generalized microvascular function.
Laser speckle contrast imaging (LSCI) is a novel, noninvasive method to assess skin …

Arterial hypertension represents a leading cause of cardiovascular mortality and morbidity
worldwide through its detrimental effects on target organs. Therefore, the early identification …

Albuminuria may be a biomarker of generalized (ie, microvascular and macrovascular)
endothelial dysfunction. According to this concept, endothelial dysfunction of the renal …

Psoriasis is associated with accelerated rates of cardiovascular disease (CVD). Laser
Speckle Contrast Imaging (LSCI) is a novel, non-interventional technique for the dynamic …

Abstract Purpose of Review To review current literature examining the presence of
subclinical micro-and macrovascular alterations in normotensive individuals and their …