Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide,
already accounting for at least half of all cases of heart failure. As most patients with HFpEF …

Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of genes involved in inflammation and immune responses. NF-κB may play an …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

Background. Inflammation and oxidative stress are involved in the initiation and progress of
heart failure (HF). However, the role of the IL6/STAT3 pathway in the pressure overload …

Purpose Several studies have reported that colchicine attenuates cardiac inflammation and
improves cardiac function in myocardial infarction and atrial fibrillation. However, no study …

Almost 200 years ago, the first evidence described by Robert Bright (1836) showed the
strong interaction between the kidneys and heart and, since then, the scientific community …

There is substantial evidence that chronic heart failure in humans and in animal models is
associated with inflammation. Ischemic interventions such as myocardial infarction lead to …

Dilated cardiomyopathy (DCM) is a heterogeneous group of myocardial diseases clinically
defined by the presence of left ventricular dilatation and contractile dysfunction. Among …

The cardiotoxicity caused by Dox chemotherapy represents a significant limitation to its
clinical application and is a major cause of late death in patients undergoing chemotherapy …