Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system
The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
Mendelian randomization applied to neurology: promises and challenges
The Mendelian randomization (MR) paradigm allows for causal inferences to be drawn
using genetic data. In recent years, the expansion of well-powered publicly available genetic …
using genetic data. In recent years, the expansion of well-powered publicly available genetic …
Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood
YT Deng, YN Ou, BS Wu, YX Yang, Y Jiang… - Molecular …, 2022 - nature.com
Genome-wide association studies (GWASs) have identified numerous risk genes for
depression. Nevertheless, genes crucial for understanding the molecular mechanisms of …
depression. Nevertheless, genes crucial for understanding the molecular mechanisms of …
Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain
Structural variants (SVs), which are genomic rearrangements of more than 50 base pairs,
are an important source of genetic diversity and have been linked to many diseases …
are an important source of genetic diversity and have been linked to many diseases …
Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease
Background Despite being twice as likely to get Alzheimer's disease (AD), African
Americans have been grossly underrepresented in AD research. While emerging evidence …
Americans have been grossly underrepresented in AD research. While emerging evidence …
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
AA Brown, JJ Fernandez-Tajes, M Hong… - Nature …, 2023 - nature.com
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …
Genetic evidence supporting a causal role of depression in Alzheimer's disease
Background Depression has been associated with a higher risk of Alzheimer's disease (AD)
in several prospective studies; however, mechanisms underlying this association remain …
in several prospective studies; however, mechanisms underlying this association remain …
Expanding causal genes for Parkinson's disease via multi-omics analysis
XJ Gu, WM Su, M Dou, Z Jiang, QQ Duan… - npj Parkinson's …, 2023 - nature.com
Genome‑wide association studies (GWASs) have revealed numerous loci associated with
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …