Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …

While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …

The lateral habenula (LHb) has recently emerged as a key brain region in the
pathophysiology of depression. However, the molecular mechanism by which LHb becomes …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

Developmental programs that generate the astonishing neuronal diversity of the nervous
system are not completely understood and thus present a major challenge for clinical …

Activity-dependent gene expression triggered by Ca 2+ entry into neurons is critical for
learning and memory, but whether specific sources of Ca 2+ act distinctly or merely supply …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

The subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated
during cortical development. NMDARs are initially dominated by GluN2B (NR2B), whereas …

Mitochondrial trafficking is influenced by neuronal activity, but it remains unclear how
mitochondrial positioning influences neuronal transmission and plasticity. Here, we use live …