The role of natural killer T cells in cancer—a phenotypical and functional approach
D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …
the innate and adaptive immune system. NKT cells can be subdivided into functional …
Natural killer T cells in cancer immunotherapy
S Nair, MV Dhodapkar - Frontiers in immunology, 2017 - frontiersin.org
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that
influence inflammatory responses. We have shown that iNKT cells, previously thought to be …
influence inflammatory responses. We have shown that iNKT cells, previously thought to be …
[HTML][HTML] Enhanced anti-lymphoma activity of CAR19-iNKT cells underpinned by dual CD19 and CD1d targeting
Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical
remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19 …
remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19 …
Adoptive transfer of invariant NKT cells as immunotherapy for advanced melanoma: a phase I clinical trial
Abstract Purpose: Invariant NKT cells (iNKT) are innate-like CD1d-restricted T cells with
immunoregulatory activity in diseases including cancer. iNKT from advanced cancer patients …
immunoregulatory activity in diseases including cancer. iNKT from advanced cancer patients …
Novel approaches to exploiting invariant NKT cells in cancer immunotherapy
BJ Wolf, JE Choi, MA Exley - Frontiers in immunology, 2018 - frontiersin.org
iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain
complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens …
complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens …
Immune reconstitution after anti-thymocyte globulin-conditioned hematopoietic cell transplantation
M Bosch, M Dhadda, M Hoegh-Petersen, Y Liu… - Cytotherapy, 2012 - Elsevier
Background aims Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-
versus-host disease (GvHD); however, its impact on immune reconstitution is relatively …
versus-host disease (GvHD); however, its impact on immune reconstitution is relatively …
The tumor microenvironment: a pitch for multiple players
The cancer microenvironment may be conceptually regarded as a pitch where the main
players are resident and non-resident cellular components, each covering a defined role …
players are resident and non-resident cellular components, each covering a defined role …
New cell sources for CAR-based immunotherapy
Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are
engineered to recognize and kill cancer cells, has achieved striking success in some …
engineered to recognize and kill cancer cells, has achieved striking success in some …
A novel function of adipocytes in lipid antigen presentation to iNKT cells
Systemic low-grade chronic inflammation has been intensively investigated in obese
subjects. Recently, various immune cell types, such as macrophages, granulocytes, helper T …
subjects. Recently, various immune cell types, such as macrophages, granulocytes, helper T …