Antibiotic resistance, typically associated with genetic changes within a bacterial population,
is a frequent contributor to antibiotic treatment failures. Antibiotic persistence and tolerance …

Chronic tuberculosis (TB) disease, which requires months-long chemotherapy with multiple
antibiotics, is defined by diverse pathological manifestations and bacterial phenotypes …

The Nix-TB clinical trial evaluated a new 6 month regimen containing three oral drugs;
bedaquiline (B), pretomanid (Pa), and linezolid (L)(BPaL regimen) for the treatment of …

The spectinamides are novel, narrow-spectrum semisynthetic analogs of spectinomycin,
modified to avoid intrinsic efflux by Mycobacterium tuberculosis. Spectinamides, including …

The control of bacterial growth is key to the prevention and treatment of tuberculosis (TB).
Granulomas represent independent foci of the host immune response that present …

Background The ability to detect evidence of Mycobacterium tuberculosis (Mtb) infection
within human tissues is critical to the study of Mtb physiology, tropism, and spatial …

Heterogeneity during Mycobacterium tuberculosis (Mtb) infection greatly impacts disease
outcome and complicates treatment. This heterogeneity encompasses many facets …

ABSTRACT A major challenge in tuberculosis (TB) therapeutics is that antibiotic exposure
leads to changes in the physiology of M. tuberculosis (Mtb), which may enable the pathogen …

Background Mycobacterium avium complex (MAC) is a group of slow-growing mycobacteria
that includes Mycobacterium avium and Mycobacterium intracellulare. MAC pulmonary …

Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the sole globally licensed vaccine
against tuberculosis despite its relatively moderate protection of acute disease through …