[HTML][HTML] Call to action to properly utilize electron microscopy to measure organelles to monitor disease

K Neikirk, EG Lopez, AG Marshall, A Alghanem… - European Journal of …, 2023 - Elsevier
This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …

Mitochondria in disease: changes in shapes and dynamics

BC Jenkins, K Neikirk, P Katti, SM Claypool… - Trends in biochemical …, 2024 - cell.com
Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex

Z Vue, E Garza‐Lopez, K Neikirk, P Katti, L Vang… - Aging cell, 2023 - Wiley Online Library
During aging, muscle gradually undergoes sarcopenia, the loss of function associated with
loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural …

Defining mitochondrial cristae morphology changes induced by aging in brown adipose tissue

A Crabtree, K Neikirk, AG Marshall, L Vang… - Advanced …, 2024 - Wiley Online Library
Mitochondria are required for energy production and even give brown adipose tissue (BAT)
its characteristic color due to their high iron content and abundance. The physiological …

Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging

Z Vue, K Neikirk, L Vang… - … of physiology-heart …, 2023 - journals.physiology.org
With sparse treatment options, cardiac disease remains a significant cause of death among
humans. As a person ages, mitochondria breakdown and the heart becomes less efficient …

Current trends in luminescence-based assessment of apoptosis

C Moldovan, A Onaciu, V Toma, RA Munteanu… - RSC …, 2023 - pubs.rsc.org
Apoptosis, the most extensively studied type of cell death, is known to play a crucial role in
numerous processes such as elimination of unwanted cells or cellular debris, growth, control …

Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

AO Hinton Jr, AU N'jai, Z Vue, C Wanjalla - Circulation Research, 2024 - Am Heart Assoc
HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …

A workshop on mitochondria for students to improve understanding of science and hypothesis forming

AG Marshall, K Neikirk, D Stephens… - Advances in …, 2023 - journals.physiology.org
There remains a clear deficiency in recruiting middle school students in science, technology,
engineering, mathematics, and medicine fields, especially for those students entering …

Quantitative assessment of morphological changes in lipid droplets and lipid–mito interactions with aging in brown adipose

A Crabtree, K Neikirk, JA Pinette… - Journal of Cellular …, 2024 - Wiley Online Library
The physical characteristics of brown adipose tissue (BAT) are defined by the presence of
multilocular lipid droplets (LDs) within the brown adipocytes and a high abundance of iron …

ATF4‐dependent increase in mitochondrial‐endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle

A Hinton Jr, P Katti, M Mungai, DD Hall… - Journal of Cellular …, 2024 - Wiley Online Library
Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are protein‐and lipid‐
enriched hubs that mediate interorganellar communication by contributing to the dynamic …