Over the past decade, dramatic increases in computational power and improvement in
image analysis algorithms have allowed the development of powerful computer-assisted …

The discovery of mutant KRAS as a predictor of resistance to epidermal growth-factor
receptor (EGFR) monoclonal antibodies brought a major change in the treatment of …

Limitations on the number of unique protein and DNA molecules that can be characterized
microscopically in a single tissue specimen impede advances in understanding the …

Purpose: Host immune response to tumor may be an important prognostic factor for colon
cancer patients. However, little is known on prognostic significance of histopathologic …

Endoscopic imaging is an invaluable diagnostic tool allowing minimally invasive access to
tissues deep within the body. It has played a key role in screening colon cancer and is …

Current breast cancer classification systems are based on molecular evaluation of tumor
receptor status and do not account for distinct morphological phenotypes. In other types of …

Abstract Purpose: Cyclooxygenase-2 (COX-2; PTGS2) is considered to play an important
role in colorectal carcinogenesis and is often up-regulated in colon cancers. However …

A robust understanding of the tumor immune environment has important implications for
cancer diagnosis, prognosis, research, and immunotherapy. Traditionally …

Colorectal cancer (CRC) is the third most common cancer and a common cause of cancer‐
related mortality globally. In spite of the improvements in the early diagnosis of CRC …

Previous small scale sequencing studies have indicated that DNA polymerase β (pol β)
variants are present on average in 30% of human tumors of varying tissue origin. Many of …