Synaptic specificity, recognition molecules, and assembly of neural circuits

JR Sanes, SL Zipursky - Cell, 2020 - cell.com
Develo** neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

Adhesion protein structure, molecular affinities, and principles of cell-cell recognition

B Honig, L Shapiro - Cell, 2020 - cell.com
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons

SK Jetti, AB Crane, Y Akbergenova… - Neuron, 2023 - cell.com
Although neuronal subtypes display unique synaptic organization and function, the
underlying transcriptional differences that establish these features are poorly understood. To …

Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons

K He, Y Han, X Li, RX Hernandez… - Journal of …, 2023 - Soc Neuroscience
Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the
circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity …

Coordination between stochastic and deterministic specification in the Drosophila visual system

M Courgeon, C Desplan - Science, 2019 - science.org
INTRODUCTION Neuronal fate decisions must be coordinated across brain regions so that
the proper stoichiometry of distinct afferents and their target neurons is established. Many …

Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits

KP Menon, V Kulkarni, S Takemura, M Anaya, K Zinn - Elife, 2019 - elifesciences.org
Drosophila R7 UV photoreceptors (PRs) are divided into yellow (y) and pale (p) subtypes.
yR7 PRs express the Dpr11 cell surface protein and are presynaptic to Dm8 amacrine …

Structural and functional synaptic plasticity induced by convergent synapse loss in the Drosophila neuromuscular circuit

Y Wang, M Lobb-Rabe, J Ashley, V Anand… - Journal of …, 2021 - Soc Neuroscience
Throughout the nervous system, the convergence of two or more presynaptic inputs on a
target cell is commonly observed. The question we ask here is to what extent converging …

Control of synaptic specificity by establishing a relative preference for synaptic partners

C Xu, E Theisen, R Maloney, J Peng, I Santiago… - Neuron, 2019 - cell.com
The ability of neurons to identify correct synaptic partners is fundamental to the proper
assembly and function of neural circuits. Relative to other steps in circuit formation such as …

Structure and evolution of neuronal wiring receptors and ligands

E Cortés, JS Pak, E Özkan - Developmental Dynamics, 2023 - Wiley Online Library
One of the fundamental properties of a neuronal circuit is the map of its connections. The
cellular and developmental processes that allow for the growth of axons and dendrites …

Synaptic properties and plasticity mechanisms of invertebrate tonic and phasic neurons

NA Aponte-Santiago, JT Littleton - Frontiers in Physiology, 2020 - frontiersin.org
Defining neuronal cell types and their associated biophysical and synaptic diversity has
become an important goal in neuroscience as a mechanism to create comprehensive brain …