Regulatory mechanism of MicroRNA expression in cancer

Z Ali Syeda, SSS Langden, C Munkhzul, M Lee… - International journal of …, 2020 - mdpi.com
Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance

MA Iqbal, S Arora, G Prakasam, GA Calin… - Molecular aspects of …, 2019 - Elsevier
Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …

Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis

Z Song, G Jia, P Ma, S Cang - Life sciences, 2021 - Elsevier
Aims Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance.
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …

The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

MicroRNA (miRNA) in cancer

KB Reddy - Cancer cell international, 2015 - Springer
In recent years, there has been a tremendous and growing interest among researchers to
investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes …

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The epigenetics of epithelial-mesenchymal plasticity in cancer

WL Tam, RA Weinberg - Nature medicine, 2013 - nature.com
During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

Lung cancer epigenetics: from knowledge to applications

M Duruisseaux, M Esteller - Seminars in cancer biology, 2018 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators

M Ashrafizadeh, A Zarrabi, K Hushmandi, F Hashemi… - Cellular signalling, 2021 - Elsevier
Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The
anti-tumor activity of CP has been demonstrated in different cancers such as breast, cervical …

MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

AL Kasinski, FJ Slack - Nature Reviews Cancer, 2011 - nature.com
In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …