Basic science of articular cartilage
CB Carballo, Y Nakagawa, I Sekiya… - Clinics in sports …, 2017 - sportsmed.theclinics.com
The hyaline cartilage is the most abundant type of cartilage in the body. It is responsible for
the bone formation in the embryo (endochondral ossification) and in adults, it can be found …
the bone formation in the embryo (endochondral ossification) and in adults, it can be found …
Role of NF-κB in ageing and age-related diseases: lessons from genetically modified mouse models
VA García-García, JP Alameda, A Page, ML Casanova - Cells, 2021 - mdpi.com
Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and
environmental factors. It is manifested by a decline in the physiological functions of …
environmental factors. It is manifested by a decline in the physiological functions of …
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
[HTML][HTML] Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future
MA Karsdal, M Michaelis, C Ladel, AS Siebuhr… - Osteoarthritis and …, 2016 - Elsevier
Osteoarthritis (OA) is the biggest unmet medical need among the many musculoskeletal
conditions and the most common form of arthritis. It is a major cause of disability and …
conditions and the most common form of arthritis. It is a major cause of disability and …
Emerging targets in osteoarthritis therapy
Highlights•Different OA etiologies present a challenge for develo** a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
[HTML][HTML] Runx2 plays a central role in Osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritis, is the leading cause of impaired
mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain …
mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain …
Inflammatory and metabolic signaling interfaces of the hypertrophic and senescent chondrocyte phenotypes associated with osteoarthritis
Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …
Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation
Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence …
cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence …
Recent insights into the contribution of the changing hypertrophic chondrocyte phenotype in the development and progression of osteoarthritis
EGJ Ripmeester, UT Timur, MMJ Caron… - … in bioengineering and …, 2018 - frontiersin.org
Osteoarthritis (OA) is an extremely prevalent age-related condition. The economic and
societal burden due to the cost of symptomatic treatment, inability to work, joint replacement …
societal burden due to the cost of symptomatic treatment, inability to work, joint replacement …
Emerging players at the intersection of chondrocyte loss of maturational arrest, oxidative stress, senescence and low‐grade inflammation in osteoarthritis
M Minguzzi, S Cetrullo, S D'Adamo… - Oxidative medicine …, 2018 - Wiley Online Library
The prevalence of Osteoarthritis (OA) is increasing because of the progressive aging and
unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly …
unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly …