Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most
common neurodegenerative disorder that causes irreversible blindness worldwide. It is …

Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease
that specifically targets the retinal ganglion cells by reducing their ability to produce enough …

Leber's hereditary optic neuropathy (LHON), a disease associated with a mitochondrial DNA
mutation, is characterized by blindness due to degeneration of retinal ganglion cells (RGCs) …

Glaucoma, an age-related neurodegenerative disease, is characterized by the death of
retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the …

Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial
genetic disease that causes blindness in young adults. Over 50 inherited mitochondrial DNA …

Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic
cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited …

Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA
(mtDNA) disorder with the majority of patients harboring one of three primary mtDNA point …

Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease mainly affecting
retinal ganglion cells (RGCs). The pathogenesis of LHON remains ill-characterized due to a …

Mitochondrial transplantation is a promising therapeutic approach for the treatment of
mitochondrial diseases caused by mutations in mitochondrial DNA, as well as several …

LHON is phenotypically more heterogeneous than previously considered and a complex
interplay of genetic, environmental and hormonal factors modulates the risk of a LHON …