Computational methods to identify metabolic sub-networks based on metabolomic profiles

C Frainay, F Jourdan - Briefings in bioinformatics, 2017 - academic.oup.com
Untargeted metabolomics makes it possible to identify compounds that undergo significant
changes in concentration in different experimental conditions. The resulting metabolomic …

HamLib: A library of Hamiltonians for benchmarking quantum algorithms and hardware

NPD Sawaya, D Marti-Dafcik, Y Ho, DP Tabor… - Quantum, 2024 - quantum-journal.org
In order to characterize and benchmark computational hardware, software, and algorithms, it
is essential to have many problem instances on-hand. This is no less true for quantum …

Prediction of metabolic pathways from genome-scale metabolic networks

K Faust, D Croes, J Van Helden - Biosystems, 2011 - Elsevier
The analysis of a variety of data sets (transcriptome arrays, phylogenetic profiles, etc.) yields
groups of functionally related genes. In order to determine their biological function …

Pathway discovery in metabolic networks by subgraph extraction

K Faust, P Dupont, J Callut, J Van Helden - Bioinformatics, 2010 - academic.oup.com
Motivation: Subgraph extraction is a powerful technique to predict pathways from biological
networks and a set of query items (eg genes, proteins, compounds, etc.). It can be applied to …

Centrality measures and thermodynamic formalism for complex networks

JC Delvenne, AS Libert - Physical Review E—Statistical, Nonlinear, and Soft …, 2011 - APS
In the study of small and large networks it is customary to perform a simple random walk
where the random walker jumps from one node to one of its neighbors with uniform …

Detecting phenotype-driven transitions in regulatory network structure

M Padi, J Quackenbush - NPJ systems biology and applications, 2018 - nature.com
Complex traits and diseases like human height or cancer are often not caused by a single
mutation or genetic variant, but instead arise from functional changes in the underlying …

An approach for concept drift detection in a graph stream using discriminative subgraphs

R Paudel, W Eberle - ACM Transactions on Knowledge Discovery from …, 2020 - dl.acm.org
The emergence of mining complex networks like social media, sensor networks, and the
world-wide-web has attracted considerable research interest. In a streaming scenario, the …

[HTML][HTML] Graph-based methods for discovery browsing with semantic predications

B Wilkowski, M Fiszman, CM Miller… - AMIA annual …, 2011 - ncbi.nlm.nih.gov
We present an extension to literature-based discovery that goes beyond making discoveries
to a principled way of navigating through selected aspects of some biomedical domain. The …

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates type 2 diabetes associated genes

A Sharma, A Halu, JL Decano, M Padi, YY Liu… - NPJ systems biology …, 2018 - nature.com
Probing the dynamic control features of biological networks represents a new frontier in
capturing the dysregulated pathways in complex diseases. Here, using patient samples …

Biomedical discovery acceleration, with applications to craniofacial development

SM Leach, H Tipney, W Feng… - PLoS computational …, 2009 - journals.plos.org
The profusion of high-throughput instruments and the explosion of new results in the
scientific literature, particularly in molecular biomedicine, is both a blessing and a curse to …