Antibiotic perturbations to the gut microbiome
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
Horizontal transfer of antibiotic resistance genes in clinical environments
A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …
generally associated with drug target modification, enzymatic inactivation, and/or transport …
Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …
Review of antimicrobial resistance in the environment and its relevance to environmental regulators
The environment is increasingly being recognized for the role it might play in the global
spread of clinically relevant antibiotic resistance. Environmental regulators monitor and …
spread of clinically relevant antibiotic resistance. Environmental regulators monitor and …
Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: roles and mechanisms
The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …
Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes
It is well established that plasmids play an important role in the dissemination of
antimicrobial resistance (AMR) genes; however, little is known about the role of the …
antimicrobial resistance (AMR) genes; however, little is known about the role of the …
Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer
Antimicrobial resistance (AMR) poses a worldwide threat to human health and biosecurity.
The spread of antibiotic resistance genes (ARGs) via conjugative plasmid transfer is a major …
The spread of antibiotic resistance genes (ARGs) via conjugative plasmid transfer is a major …
Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
[HTML][HTML] Evolution of plasmid-mediated antibiotic resistance in the clinical context
A San Millan - Trends in microbiology, 2018 - cell.com
Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply
increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance …
increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance …