Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

The immune system is a complex network of cells with critical functions in health and
disease. However, a comprehensive census of the cells comprising the immune system is …

Immune memory is tailored by cues that lymphocytes perceive during priming. The severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

Tissue resident memory CD8+ T (TRM) cells offer rapid and long-term protection at sites of
reinfection. Tumour-infiltrating lymphocytes with characteristics of TRM cells maintain …

Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex
immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in …

Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …

With the burgeoning use of immune-based treatments for cancer, never has there been a
greater need to understand the tumour microenvironment within which immune cells …