To provide a stable environmental barrier, the epidermis requires an integrated network of
cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain
multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold …

Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells
by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate …

Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in
evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate …

Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues.
Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and …

Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and
mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein …

Desmosomes are intercellular junctions that anchor intermediate filaments (IFs) to the
plasma membrane, forming a supracellular scaffold that provides mechanical resilience to …

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by
autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg) 1 …

Adherens junctions, which are intercellular adhesive complexes that are crucial for
maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour …