Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

All tissue-resident macrophages of the central nervous system (CNS)—including
parenchymal microglia, as well as CNS-associated macrophages (CAMs) such as …

Aims Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic
cells (DCs)] in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Interplay between innate and adaptive immune cells is important for the antitumor immune
response. However, the tumor microenvironment may turn immune suppressive, and tumor …

Tissue-resident macrophages are present in most tissues with developmental, self-renewal,
or functional attributes that do not easily fit into a textbook picture of a plastic and …

Stroke is a leading cause of disability and mortality, with limited treatment options. After
stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate …

As the resident macrophages of the brain and spinal cord, microglia are crucial for the
phagocytosis of infectious agents, apoptotic cells and synapses. During brain injury or …