Transcriptome profiling studies have recently uncovered a large number of noncoding RNA
transcripts (ncRNAs) in eukaryotic organisms, and there is growing interest in their role in …

The budding yeast Saccharomyces cerevisiae has three cell types (a cells, α cells, and a/α
cells), each of which is specified by a unique combination of transcriptional regulators. This …

Displacement loops (D-loops) are critical intermediates formed during homologous
recombination. Rdh54 (aka Tid1), a Rad54 paralog in Saccharomyces cerevisiae, is well …

Cell polarization in response to chemical gradients is important in development and
homeostasis across eukaryota. Chemosensing cells orient toward or away from gradient …

The field of high-throughput genetic experimentation is evolving rapidly, with the advent of
new technologies and new venues for data mining. Bayesian methods play a role central to …

Proper DNA damage repair is one of the most vital and fundamental functions of every cell.
Several different repair mechanisms exist to deal with various types of DNA damage, in …

Background Acute myeloid leukemia (AML) comprises a group of diseases characterized by
the abnormal development of malignant myeloid cells. Recent studies have demonstrated …

Background Effects on gene expression due to environmental or genetic changes can be
easily measured using microarrays. However, indirect effects on expression can be …

The HO gene in Saccharomyces cerevisiae is regulated by a large and complex promoter
that is similar to promoters in higher order eukaryotes. Within this promoter are 10 potential …

Prediction of biological functions of genes is an important issue in basic biology research
and has applications in drug discoveries and gene therapies. Previous studies have shown …