α‐Enolase is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells
and is considered a multifunctional protein. α‐enolase is expressed on the surface of …

In this paper, we present a systematic and conceptual overview of methods for inferring
gene regulatory networks from observational gene expression data. Further, we discuss two …

To target complex, multi-factorial diseases more effectively, there has been an emerging
trend of multi-target drug development based on network biology, as well as an increasing …

Colorectal cancer (CRC) is the third most common cancer worldwide and has poor
prognosis. To identify the oncofetal proteins involved in CRC carcinogenesis, differentially …

Chronic inflammation is a risk factor for several gastrointestinal malignancies, including
colorectal cancer. Recent epidemiological studies and clinical trials demonstrate that long …

The α‐enolase (ENO1) plays pivotal roles in several types of cancer, but its clinical
significance, functional role, and possible mechanism in colorectal cancer (CRC) have …

Longitudinal blood collections from cohort studies provide the means to search for proteins
associated with disease before clinical diagnosis. We investigated plasma samples from the …

Abstract FBXW7 (F-box and WD40 domain protein 7) is a tumor suppressor frequently
inactivated in human cancers. The precise molecular mechanisms by which FBXW7 exerts …

Gene regulatory networks inferred from RNA abundance data have generated significant
interest, but despite this, gene network approaches are used infrequently and often require …

In the present study, we investigated the effect of reduced enolase-1 expression in human
umbilical vein endothelial cells (HUVECs)/MDA-MB-231 cells on the response to hypoxia …