Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

Restoring gene flow into small, isolated populations can alleviate genetic load and decrease
extinction risk (ie, genetic rescue), yet gene flow is rarely augmented as a conservation …

The unprecedented rate of extinction calls for efficient use of genetics to help conserve
biodiversity. Several recent genomic and simulation-based studies have argued that the …

Understanding the factors that cause endangered populations to either grow or decline is
crucial for preserving biodiversity. Conservation efforts often address extrinsic threats, such …

The kākāpō is a flightless parrot endemic to New Zealand. Once common in the archipelago,
only 201 individuals remain today, most of them descending from an isolated island …

Genetic rescue–ameliorating inbreeding depression and restoring genetic diversity of inbred
populations through gene flow-is valuable in wildlife conservation. Empirically validated …

Increasing habitat fragmentation leads to wild populations becoming small, isolated, and
threatened by inbreeding depression. However, small populations may be able to purge …

The observation that small isolated populations often suffer reduced fitness from inbreeding
depression has guided conservation theory and practice for decades. However …

Animal and plant species around the world are being challenged by the deleterious effects
of inbreeding, loss of genetic diversity, and maladaptation due to widespread habitat …

Human-driven habitat fragmentation and loss have led to a proliferation of small and
isolated plant and animal populations with high risk of extinction. One of the main threats to …