Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells.
Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

The variability of the postsynaptic response following a single action potential arises from
two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to …

A seminal event in the pathogenesis of Alzheimer's disease (AD) is the abnormal proteolytic
processing of amyloid precursor protein (APP), resulting in increased production of a …

We explored the idea of whether electropotential waves (EPWs) primarily act as vehicles for
systemic spread of Ca2+ signals. EPW-associated Ca2+ influx may trigger generation and …

Ca2+ regulates a multitude of cellular processes and does so by partitioning its actions in
space and time. In this review, we discuss how Ca2+ responses are constructed from small …

Damage induces remote occlusion of sieve tubes in Vicia faba by forisome dispersion,
triggered during the passage of an electropotential wave (EPW). This study addresses the …

Vacuoles play various roles in many physiologically relevant processes in plants. Some of
the more prominent are turgor provision, the storage of minerals and nutrients, and cellular …