Biotechnological advances in the synthesis of modified chondroitin towards novel biomedical applications

D Cimini, E Bedini, C Schiraldi - Biotechnology Advances, 2023 - Elsevier
Chondroitin sulfate (CS) is a well-known glycosaminoglycan present in a large variety of
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …

Marine biocompounds for neuroprotection—A review

AF Bălașa, C Chircov, AM Grumezescu - Marine Drugs, 2020 - mdpi.com
While terrestrial organisms are the primary source of natural products, recent years have
witnessed a considerable shift towards marine-sourced biocompounds. They have achieved …

Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients

W Palinski, M Monti, R Camerlingo, I Iacobucci… - Cell death & …, 2021 - nature.com
The tumor microenvironment modulates cancer growth. Extracellular vesicles (EVs) have
been identified as key mediators of intercellular communication, but their role in tumor …

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer's disease associated with obesity, metabolic syndrome, and …

ME De Sousa Rodrigues, MC Houser… - Alzheimer's research & …, 2020 - Springer
Background Insulin impairment and inflammation are two features common to type 2
diabetes and Alzheimer's disease; however, the molecular and signaling interactions …

BDE-209 disrupted the blood-testis barrier integrity by inhibiting estrogen receptor α signaling pathway in Sprague–Dawley rats

X Geng, Y Wei, W Geng, T Zhang, T Ding, J Xu… - … Science and Pollution …, 2023 - Springer
Deca brominated diphenyl ether (BDE-209) is a widely used flame retardant with endocrine-
disrupting activity which reportedly caused sperm quality decline and damaged blood-testis …

Hydroxytyrosol selectively affects non-enzymatic glycation in human insulin and protects by AGEs cytotoxicity

I Sirangelo, M Borriello, M Liccardo, M Scafuro… - Antioxidants, 2021 - mdpi.com
Hydroxytyrosol (HT), the major phenolic compound in olive oil, is attracting increasing
interest for its beneficial properties including a notable antioxidant and anti-inflammatory …

Production and purification of higher molecular weight chondroitin by metabolically engineered Escherichia coli K4 strains

S D'ambrosio, A Alfano, E Cassese, OF Restaino… - Scientific Reports, 2020 - nature.com
The capsular polysaccharide obtained from Escherichia coli K4 is a glycosaminoglycan-like
molecule, similar to chondroitin sulphate, that has established applications in the biomedical …

[HTML][HTML] Dairy liquid waste as substrate to obtain biotechnological chondroitin: A circular economy approach

S D'ambrosio, A Alfano, C Schiraldi, D Cimini - Food and Bioproducts …, 2024 - Elsevier
Microbial polysaccharides have been gaining growing interest often as alternative to animal
derived products or as sources of novel features for biotechnological applications. Process …

Pinocembrin protects from AGE-induced cytotoxicity and inhibits non-enzymatic glycation in human insulin

M Borriello, C Iannuzzi, I Sirangelo - Cells, 2019 - mdpi.com
Advanced glycation end products (AGEs) are the end products of the glycation reaction and
have a great importance in clinical science for their association with oxidative stress and …

Hydroxytyrosol inhibits protein oligomerization and amyloid aggregation in human insulin

I Sirangelo, M Borriello, S Vilasi, C Iannuzzi - International Journal of …, 2020 - mdpi.com
Hydroxytyrosol (HT), one of the main phenolic components of olive oil, has attracted
considerable interest for its biological properties, including a remarkable antioxidant and …