Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current Insights and Future Directions

Y Gu, X Zhao, N Zhang, Y Yang, Y Yi, Q Shao… - Ageing Research …, 2024 - Elsevier
Neurodegenerative diseases, as common diseases in the elderly, tend to become younger
due to environmental changes, social development and other factors. They are mainly …

Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases

J Liang, Y Zhu, S Liu, B Kuang, Z Tian… - Phytotherapy …, 2024 - Wiley Online Library
Exosomes, extracellular vesicles secreted by various cells, actively participate in
intercellular communication by facilitating the exchange of crucial molecular information …

Ginsenoside Rg2 alleviates astrocyte inflammation and ameliorates the permeability of the Alzheimer's disease related blood-brain barrier

Y Lu, Y Wang, Z Wang, S Ren, X Gong, J Hu, J Zhang… - Phytomedicine, 2024 - Elsevier
Background Damage to the blood-brain barrier (BBB) is vital for the development of
Alzheimer's disease (AD). Ginsenoside Rg2 (G-Rg2) has been shown to improve a variety of …

[HTML][HTML] Ginsenoside RK1 induces ferroptosis in hepatocellular carcinoma cells through an FSP1-dependent pathway

Y Jiang, Y Yu, Z Pan, Z Wang, M Sun - Pharmaceuticals, 2024 - mdpi.com
Background: Hepatocellular carcinoma (HCC), currently ranking as the third most lethal
malignancy, poses a grave threat to human health. Ferroptosis, a form of programmed cell …

Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products

G Chen, Y Zhang, Y Zhou, H Luo… - Journal of Inflammation …, 2024 - Taylor & Francis
Despite advancements in cancer treatment through surgery and drugs, hepatocellular
carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The …

[HTML][HTML] Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology …

M Jiang, J Chi, Y Qiao, J Wang, Z Zhang, J Liu… - Pharmacological …, 2025 - Elsevier
Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for
thousands of years. Ginsenosides are the main pharmacologically active ingredients …

[HTML][HTML] Biological effects and mechanism of β-amyloid aggregation inhibition by penetrable recombinant human HspB5-ACD structural domain protein

C Liu, X Ding, M Zhao, C Chen, X Zhang… - Biomedicine & …, 2024 - Elsevier
Alzheimer's disease (AD) is a global medical challenge. Studies have shown that
neurotoxicity caused by pathological aggregation of β-amyloid (Aβ) is an important factor …

Exploring the antimicrobial activity of rare ginsenosides and the progress of their related pharmacological effects

W Wang, Y Xue, J Zhou, Z Zhang, S Guo, C Zhao, Y Bai… - Phytomedicine, 2024 - Elsevier
Abstract Background Panax ginseng CA Mey is a precious medicinal resource that could be
used to treat a variety of diseases. Saponins are the most important bioactive components …

Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells

C Song, Z Chu, J Dai, D **e, T Qin, L **e, Z Zhai… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Moschus, first described in the Shennong's Classic of the
Materia medicine, is a scarce and precious animal medicine. Modern pharmacological …

SENP1 inhibits aerobic glycolysis in Aβ1-42-incubated astrocytes by promoting PUM2 deSUMOylation

Q Liu, M Jiang, Z Wang, J Meng, J Li, J Lin… - Cell Biology and …, 2025 - Springer
Abstract Alzheimer's disease (AD), the most prevalent form of dementia in the elderly,
involves critical changes such as reduced aerobic glycolysis in astrocytes and increased …