ABC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …
living organisms. The processes are usually mediated by specific transporters. One of the …
Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter
SPC Cole - Journal of Biological Chemistry, 2014 - ASBMB
The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …
Toxicity of amphetamines: an update
Amphetamines represent a class of psychotropic compounds, widely abused for their
stimulant, euphoric, anorectic, and, in some cases, emphathogenic, entactogenic, and …
stimulant, euphoric, anorectic, and, in some cases, emphathogenic, entactogenic, and …
Arsenic exposure and cognitive performance in Mexican schoolchildren
Background Previous studies have suggested an effect of high arsenic concentration on
cognitive and neurobehavioral function in humans. Objective Our goal was to identify …
cognitive and neurobehavioral function in humans. Objective Our goal was to identify …
Transport of glutathione and glutathione conjugates by MRP1
Glutathione (GSH)-conjugated xenobiotics and GSH-conjugated metabolites (eg the
cysteinyl leukotriene C 4) must be exported from the cells in which they are formed before …
cysteinyl leukotriene C 4) must be exported from the cells in which they are formed before …
Amphetamine toxicities: classical and emerging mechanisms
The drugs of abuse, methamphetamine and MDMA, produce long‐term decreases in
markers of biogenic amine neurotransmission. These decreases have been traditionally …
markers of biogenic amine neurotransmission. These decreases have been traditionally …
Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview
Abstract “Ecstasy”[(±)-3, 4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a
psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse …
psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse …
Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse
KC Schmitt, MEA Reith - Annals of the New York Academy of …, 2010 - Wiley Online Library
Dopaminergic signaling in the brain is primarily modulated by dopamine transporters
(DATs), which actively translocate extraneuronal dopamine back into dopaminergic …
(DATs), which actively translocate extraneuronal dopamine back into dopaminergic …
Piperazine compounds as drugs of abuse
Synthetic drugs are among the most commonly abused drugs in the world. This abuse is
widespread among young people, especially in the dance club and rave scenes. Over the …
widespread among young people, especially in the dance club and rave scenes. Over the …
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and d-amphetamine
Abstract Amphetamine ('Speed'), methamphetamine ('Ice') and its congener 3, 4-
methylenedioxymethamphetamine (MDMA;'Ecstasy') are illicit drugs abused worldwide for …
methylenedioxymethamphetamine (MDMA;'Ecstasy') are illicit drugs abused worldwide for …