The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Over the past two decades, there has been increasing interest in the impact of internet use
and growing concern about whether problematic use of the internet (PUI) constitutes an …

For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

Summary Since 1997 the US National Institute on Drug Abuse has advocated a brain
disease model of addiction (BDMA). We assess the strength of evidence for the BDMA in …

Many recognize that several behaviors potentially affecting the reward circuitry in human
brains lead to a loss of control and other symptoms of addiction in at least some individuals …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …

In the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5),
gambling disorder was recategorized from the “Impulse Control Disorder” section to the …

Background A large proportion of adolescents drink alcohol, with many engaging in high-
risk patterns of consumption, including binge drinking. Here, we systematically review and …

Substance abuse is a public health problem, and it is estimated that around 12 per cent of
the total number of drug users have some substance use disorder (SUD). According to the …