Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals
M Solares-Briones, G Coyote-Dotor, JC Páez-Franco… - Pharmaceutics, 2021 - mdpi.com
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …
diverse molecular compounds and has become an important synthetic tool in different fields …
Pillararene-based variable stoichiometry co-crystallization: a versatile approach to diversified solid-state superstructures
Variable stoichiometry co-crystals are important in solid-state supramolecular chemistry as
they allow studies of structure–property relationships while permitting the synthesis of new …
they allow studies of structure–property relationships while permitting the synthesis of new …
Co‐crystal Prediction by Artificial Neural Networks
JJ Devogelaer, H Meekes, P Tinnemans… - Angewandte Chemie …, 2020 - Wiley Online Library
A significant amount of attention has been given to the design and synthesis of co‐crystals
by both industry and academia because of its potential to change a molecule's …
by both industry and academia because of its potential to change a molecule's …
Reactive crystallization: a review
MA McDonald, H Salami, PR Harris… - Reaction Chemistry & …, 2021 - pubs.rsc.org
Reactive crystallization is not new, but there has been recent growth in its use as a means of
improving performance and sustainability of industrial processes. This review examines …
improving performance and sustainability of industrial processes. This review examines …
Cocrystals by design: a rational coformer selection approach for tackling the API problems
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …
stability present a significant challenge during their processing into final dosage forms …
Macrocycle Co‐Crystals Showing Vapochromism to Haloalkanes
Organic co‐crystal engineering is a promising method to make multifunctional materials.
Here, the marriage of macrocyclic chemistry and co‐crystal engineering provides a smart …
Here, the marriage of macrocyclic chemistry and co‐crystal engineering provides a smart …
Amino acids as the potential co-former for co-crystal development: a review
I Nugrahani, MA Jessica - Molecules, 2021 - mdpi.com
Co-crystals are one of the most popular ways to modify the physicochemical properties of
active pharmaceutical ingredients (API) without changing pharmacological activity through …
active pharmaceutical ingredients (API) without changing pharmacological activity through …
Opportunities and challenges in mechanochemical cocrystallization toward scaled-up pharmaceutical manufacturing
Recently, pharmaceutical cocrystals have gained immense interest because of their
potential to tune mechanical, pharmacokinetic, and physicochemical properties of active …
potential to tune mechanical, pharmacokinetic, and physicochemical properties of active …
Spray drying as an advantageous strategy for enhancing pharmaceuticals bioavailability
AH Salama - Drug Delivery and Translational Research, 2020 - Springer
Spray drying is an efficient technique that is used not only for rapid evaporation of the
solvent from different systems but also for designing ultra-fine particles with various …
solvent from different systems but also for designing ultra-fine particles with various …