Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …

The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a
variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

The articular cartilage has insufficient intrinsic healing abilities, and articular cartilage
injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials …

The predominant proteoglycan present in cartilage is the large chondroitin sulfate
proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a …

Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Cartilage is a soft connective tissue that is composed of a single cell type, chondrocyte, and
a highly specialized extracellular matrix (ECM). Three major types of cartilaginous tissues …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

The biology of basement membrane proteoglycans extends far beyond the original notion of
anionic filters. These complex molecules have dual roles as structural constituents of …

Heparan sulfate (HS) is a complex and highly active biopolymer that is synthesized as an
alternating copolymer of hexuronic acid and glucosamine and modified at various positions …