Cancer-associated fibroblasts in gastrointestinal cancer
The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
The lysyl oxidase family represents a promising target in stromal targeting of solid tumors
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …
Randomized phase III trial of pegvorhyaluronidase alfa with nab-paclitaxel plus gemcitabine for patients with hyaluronan-high metastatic pancreatic adenocarcinoma
E Van Cutsem, MA Tempero, D Sigal, DY Oh… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE To evaluate the efficacy and safety of pegvorhyaluronidase alfa (PEGPH20) plus
nab-paclitaxel/gemcitabine (AG) in patients with hyaluronan-high metastatic pancreatic …
nab-paclitaxel/gemcitabine (AG) in patients with hyaluronan-high metastatic pancreatic …
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
T Zhang, Y Ren, P Yang, J Wang, H Zhou - Cell Death & Disease, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …
CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer
Cancer-associated fibroblasts (CAFs) are one of the most significant components in the
tumour microenvironment (TME), where they can perform several protumourigenic functions …
tumour microenvironment (TME), where they can perform several protumourigenic functions …
Phase IB/II randomized study of FOLFIRINOX plus pegylated recombinant human hyaluronidase versus FOLFIRINOX alone in patients with metastatic pancreatic …
RK Ramanathan, SL McDonough, PA Philip… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE Pegylated recombinant human hyaluronidase (PEGPH20) degrades hyaluronan
(HA) and, in combination with chemotherapy, prolongs survival in preclinical models. The …
(HA) and, in combination with chemotherapy, prolongs survival in preclinical models. The …
[HTML][HTML] Microenvironmental determinants of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
[HTML][HTML] Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies
Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …