Oncoimmunology represents a biomedical research discipline coined to study the roles of
immune system in cancer progression with the aim of discovering novel strategies to arm it …

Following the general aim of recapitulating the native mechanical properties of tissues and
organs in vitro, the field of materials science and engineering has benefited from recent …

Constructing an engineered hepatic lobule-mimetic model is challenging owing to
complicated lobular architecture and crucial hepatic functionality. Our previous study has …

Drug-induced liver injury (DILI) is a leading cause of attrition in drug development or
withdrawal; current animal experiments and traditional 2D cell culture systems fail to …

Acoustic levitation, which allows contactless manipulation of micro‐objects with ultrasounds,
is a promising technique for spheroids formation and culture. This acoustofluidic technique …

Loss of differentiation of primary human hepatocytes (PHHs) ex vivo is a known problem of
in vitro liver models. Culture optimizations using collagen type I and Matrigel reduce the …

Hypothesis The selective permeation of molecules and nanomedicines across the diseased
vasculature dictates the success of a therapeutic intervention. Yet, in vitro assays cannot …

Organ-on-a-chip platform scans offer a controllable environment and a physiological
similarity to mimic human pathophysiology. In this study, a single-channel PDMS microchip …

This work analyzes the role of the tight junction (TJ) protein ZO-2 on mechanosensation. We
found that the lack of ZO-2 reduced apical membrane rigidity measured with atomic force …

While a significant number of studies have focused on elucidating the functioning
mechanisms of the Hepatocellular carcinoma (HCC) microenvironment, the intercellular …