Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …

Background The disruption of the neurovascular unit (NVU), which maintains the integrity of
the blood brain barrier (BBB), has been identified as a critical mechanism in the …

Exposure to air pollution has been associated with increased dementia. However, it remains
unknown what specific metabolic mechanisms play a role in this relationship. We included …

Background Neurofilament Light Chain (NfL) is a biomarker of axonal injury elevated in mild
cognitive impairment (MCI) and Alzheimer's disease dementia. Blood NfL also inversely …

In the brain, the extracellular matrix (ECM) composition shapes the neuronal
microenvironment and can undergo substantial changes with cerebral pathology. Brevican …

Vascular cognitive impairment (VCI) encompasses a wide range of cognitive disorders
stemming from cerebrovascular issues, such as strokes or small vessel disease. These …

Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological
mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities …

Cerebrovascular disease (CVD) is the second leading cause of dementia worldwide. The
accurate detection of vascular cognitive impairment (VCI) in CVD patients remains an …

Objective Executive dysfunction is a core symptom of vascular cognitive impairment (VCI),
which seriously affects patients' prognosis. This paper aims to investigate the effectiveness …

BACKGROUND: Endothelial dysfunction and inflammation have been implicated in the
pathophysiology of cerebral small vessel disease (SVD). However, whether they are causal …